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This process supplies the needed energy of certain organs, especially the brain. Production of ketone bodies by breaking down fatty acids and ketogenic amino acids.Persistence of a compensatory anti-inflammatory innate immune response following an insult such as sepsis or trauma.Generation of ATP through degradation of glucose, usually associated with anaerobic conditions.Metabolic process in which glucose is formed from smaller precursors, such as amino acids and glycerol.Provides a practical method for assessment of impairment of conscious level based on eye, verbal, and motor criteria.
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Free fatty acids can be used as an immediate source of energy by many organs and can be converted by the liver into ketone bodies. A non-esterified fatty acid, released by the hydrolysis of triglycerides within adipose tissue.Heritable chemical changes of the genome, such as DNA methylation or histone modification, that modifies gene expression but does not change the DNA nucleotide sequence itself.A system of molecules that pass electrons from one to another via redox reactions coupled with the transfer of protons across the inner membrane of mitochondria, creating a proton gradient that drives ATP synthesis.Defense strategy limiting the pathologic outcome of infections by preventing tissue damage or ameliorating tissue function without interfering with host's pathogen load.glycose-lactate cycle: metabolic pathway in which lactate produced by anaerobic glycolysis in the muscles moves to the liver and is converted to glucose, which in turn is metabolized back to lactate in the muscles. It involves a combination of three insults: tissue trauma due to laparotomy, necrosis caused by ligation of the cecum, and infection due to the leakage of peritoneal microbial flora into the peritoneum. One of the most stringent models of sepsis.Cecal ligation and puncture (CLP) model.Process that breaks down molecules into smaller units.Metabolic pathway in which fatty acids are metabolized to generate energy.Warburg observed that cancer cells generate energy (ATP) through high rates of glycolysis, rather than through oxidative phosphorylation. Warburg effect: first described by Otto Warburg as a characteristic of cancer cells.